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The simple fact that hair decline is cumulative with age although androgen levels fall as *** well as *** point that finasteride does not reverse sophisticated stages of androgenetic alopecia continues to be a ***stery, but probable explanations are bigger conversion of testosterone to DHT locally with age as increased degrees of five-alpha reductase are famous in balding scalp, and increased ranges of DNA harm in *** dermal papilla as effectively as senescence of *** dermal papilla *** to androgen receptor activation and environmental tension. The testicular secretion of testosterone possibly "units *** stage" for androgenic alopecia as a multifactorial dia***sis tension model, linked to hormonal predisposition, ecosystem, and age.
Free testosterone decreases in gentlemen by age eighty to amounts double that of a lady at age twenty. About 30% of normal male testosterone amount, *** approximate stage in ladies, is not enough to induce alopecia sixty%, closer to *** total found in aged gentlemen, is sufficient.
The ratio of T/SHBG, DHT/SHBG decreases by as considerably as 80% by age eighty, in numeric parallel to hair decline, and approximates *** pharmacology of antiandrogens such as finasteride.

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